The earliest known remnants in the region were found at Peers Cave in Fish Hoek and date to between 15,000 and 12,000 years ago. Little is known of the history of the region's first residents, since there is no written history from the area before it was first mentioned by Portuguese explorer Bartolomeu Dias in 1488 who was the first European to reach the area and named it "Cape of Storms" (Cabo das Tormentas). It was later renamed by John II of Portugal as "Cape of Good Hope" (Cabo da Boa Esperança) because of the great optimism engendered by the opening of a sea route to India and the East. Vasco da Gama recorded a sighting of the Cape of Good Hope in 1497. In 1510, at the Battle of Salt River, Francisco de Almeida and fifty of his men were killed and his party were defeated by ox-mounted !Uriǁ’aekua ("Goringhaiqua" in Dutch approximate spelling), which was one of the so-called Khoekhoe clans of the area that also included the !Uriǁ’aeǀ’ona ("Goringhaicona" in Dutch approximate spelling, also known as "Strandlopers"), said to be the ancestors of the !Ora nation of today. In the late 16th century, Portuguese, French, Danish, Dutch and English but mainly Portuguese ships regularly continued to stop over in Table Bay en route to the Indies. They traded tobacco, copper and iron with the Khoekhoe-speaking clans of the region, in exchange for fresh meat.

In 1652, Jan van Riebeeck and other employees of the United East India Company (Dutch: Verenigde Oost-indische Compagnie, VOC) were sent to the Cape to establish a way-station for ships travelling to the Dutch East Indies, and the Fort de Goede Hoop (later replaced by the Castle of Good Hope). The settlement grew slowly during this period, as it was hard to find adequate labour. This labour shortage prompted the authorities to import slaves from Indonesia and Madagascar. Many of these became ancestors of the first Cape Coloured communities. Under Van Riebeeck and his successors as VOC commanders and later governors at the Cape, an impressive range of useful plants were introduced to the Cape – in the process changing the natural environment forever. Some of these, including grapes, cereals, ground nuts, potatoes, apples and citrus, had an important and lasting influence on the societies and economies of the region.

The Dutch Republic being transformed in Revolutionary France's vassal Batavian Republic, Great Britain moved to take control of its colonies. Britain captured Cape Town in 1795, but the Cape was returned to the Dutch by treaty in 1803. British forces occupied the Cape again in 1806 following the Battle of Blaauwberg. In the Anglo-Dutch Treaty of 1814, Cape Town was permanently ceded to the United Kingdom. It became the capital of the newly formed Cape Colony, whose territory expanded very substantially through the 1800s. With expansion came calls for greater independence from the UK, with the Cape attaining its own parliament (1854) and a locally accountable Prime Minister (1872). Suffrage was established according to the non-racial, but sexist Cape Qualified Franchise.

During the 1850s and 1860s additional plant species were introduced from Australia by the British authorities. Notably rooikrans to stabilise the sand of the Cape Flats to allow for a road connecting the peninsula with the rest of the African continent and eucalyptus to drain marshes so as to help to eliminate malaria. In 1859 the first railway line was built and system of railways radically expanded in the 1870s. The discovery of diamonds in Griqualand West in 1867, and the Witwatersrand Gold Rush in 1886, prompted a flood of immigrants to South Africa. In 1895 the city's first public power station, the Graaff Electric Lighting Works, was opened. Conflicts between the Boer republics in the interior and the British colonial government resulted in the Second Boer War of 1899–1902, which Britain won. From 1891 to 1901 the city's population more then doubled from 67,000 to 171,000.

In 1910, Britain established the Union of South Africa, which unified the Cape Colony with the two defeated Boer Republics and the British colony of Natal. Cape Town became the legislative capital of the Union, and later of the Republic of South Africa.

Prior to the mid-twentieth century the Cape Town was arguably the most racially integrated city in the South Africa. In the 1948 national elections, the National Party won on a platform of apartheid (racial segregation) under the slogan of "swart gevaar". This led to the erosion and eventual abolition of the Cape's multiracial franchise, as well as to the Group Areas Act, which classified all areas according to race. Formerly multi-racial suburbs of Cape Town were either purged of residents deemed unlawful by apartheid legislation or demolished. The most infamous example of this in Cape Town was District Six. After it was declared a whites-only region in 1965, all housing there was demolished and over 60,000 residents were forcibly removed. Many of these residents were relocated to the Cape Flats. Under apartheid, the Cape was considered a "Coloured labour preference area", to the exclusion of "Bantus", i.e. Africans. The implementation of this policy was widely opposed by trade unions, civil society and opposition parties. It is notable that this policy was not advocated for by any coloured person, and its implementation was a unilateral decision by the apartheid government.

School students from Langa, Gugulethu and Nyanga in Cape Town reacted to the news of protests against Bantu Education in Soweto in June 1976 and organised gatherings and marches, which were met with resistance from the police. A number of school buildings were burnt down.

Cape Town was home to many leaders of the anti-apartheid movement. On Robben Island, a former penitentiary island 10 kilometres (6 miles) from the city, many famous political prisoners were held for years. In one of the most famous moments marking the end of apartheid, Nelson Mandela made his first public speech since his imprisonment, from the balcony of Cape Town City Hall hours after being released on 11 February 1990. His speech heralded the beginning of a new era for the country, and the first democratic election, was held four years later, on 27 April 1994. Nobel Square in the Victoria & Alfred Waterfront features statues of South Africa's four Nobel Peace Prize winners: Albert Luthuli, Desmond Tutu, F. W. de Klerk and Nelson Mandela.

UNESCO declared Robben Island in the Western Cape a World Heritage Site in 1999. Robben Island is located in Table Bay, some 6 km (3.7 mi) west of Bloubergstrand in Cape Town, and stands some 30m above sea level. Robben Island has been used as a prison where people were isolated, banished and exiled to for nearly 400 years. It was also used as a leper colony, a post office, a grazing ground, a mental hospital, and an outpost.

Currently visitors can only access the island via the Robben Island Museum boat service, which runs three times daily until the beginning of the peak season (1 September). The ferries depart from the Nelson Mandela Gateway at the V&A Waterfront.

Cape Town has a warm Mediterranean climate (Köppen "Csb"), with mild, moderately wet winters and dry, warm summers. Winter, which lasts from the beginning of June to the end of August, may see large cold fronts entering for limited periods from the Atlantic Ocean with significant precipitation and strong north-westerly winds. Winter months in the city average a maximum of 18 °C (64 °F) and minimum of 8.5 °C (47 °F). Total annual rainfall in the city averages 515 millimetres (20.3 in) although in the southern suburbs, close to the mountains, rainfall is significantly higher and averages closer to 1000 millimetres (40 in). Summer, which lasts from December to March, is warm and dry with an average maximum of 26 °C (79 °F) and minimum of 16 °C (61 °F). The region can get uncomfortably hot when the Berg Wind, meaning "mountain wind", blows from the Karoo interior for a couple of weeks in February or March. Spring and summer generally feature a strong wind from the south-east, known locally as the south-easter or the Cape Doctor, so called because it blows air pollution away. This wind is caused by a high-pressure system which sits in the South Atlantic to the west of Cape Town, known as the South Atlantic High. Cape Town receives 3,100 hours of sunshine per year.

Water temperatures range greatly, between 10 °C (50 °F) on the Atlantic Seaboard, to over 22 °C (72 °F) in False Bay. Average annual Ocean temperatures are between 13 °C (55 °F) on the Atlantic Seaboard (similar to Californian waters, such as San Francisco or Big Sur), and 17 °C (63 °F) in False Bay (similar to Northern Mediterranean temperatures, such as Nice or Monte Carlo).

Located in a CI Biodiversity hotspot as well as the unique Cape Floristic Region, the city of Cape Town has one of the highest levels of biodiversity of any equivalent area in the world. These protected areas are a World Heritage Site, and an estimated 2,200 species of plants are confined to Table Mountain – more than exist in the whole of the United Kingdom which has 1200 plant species and 67 endemic plant species. Many of these species, including a great many types of proteas, are endemic to the mountain and can be found nowhere else.

It is home to a total of 19 different vegetation types, of which several are endemic to the city and occur nowhere else in the world. It is also the only habitat of hundreds of endemic species, and hundreds of others which are severely restricted or threatened. This enormous species diversity is mainly because the city is uniquely located at the convergence point of several different soil types and micro-climates.

Table Mountain has an unusually rich biodiversity. Its vegetation consists predominantly of several different types of the unique and rich Cape Fynbos. The main vegetation type is endangered Peninsula Sandstone Fynbos, but critically endangered Peninsula Granite Fynbos, Peninsula Shale Renosterveld and Afromontane forest occur in smaller portions on the mountain.

Unfortunately, rapid population growth and urban sprawl has covered much of these ecosystems with development. Consequently, Cape Town now has over 300 threatened plant species and 13 which are now extinct. The Cape Peninsula, which lies entirely within the city of Cape Town, has the highest concentration of threatened species of any continental area of equivalent size in the world. Tiny remnant populations of critically endangered or near extinct plants sometimes survive on road sides, pavements and sports fields. The remaining ecosystems are partially protected through a system of over 30 nature reserves – including the massive Table Mountain National Park.

Cape Town reached first place in the 2019 iNaturalist City Nature Challenge in two out of the three categories: Most Observations, and Most Species. This was the first entry by Capetonians in this annual competition to observe and record the local biodiversity over a four-day long weekend during what is considered the worst time of the year for local observations. However, a worldwide survey showed that the extinction rate of endemic plants from the City of Cape Town is one of the highest in the world, at roughly three per year since 1900 - partly a consequence of the very small and localised habitats and high endemicity.

The City Bowl is a natural amphitheatre-shaped area bordered by Table Bay and defined by the mountains of Signal Hill, Lion's Head, Table Mountain and Devil's Peak.

The area includes the central business district of Cape Town, the harbour, the Company's Garden, and the residential suburbs of De Waterkant, Devil's Peak, District Six, Zonnebloem, Gardens, Bo-Kaap, Higgovale, Oranjezicht, Schotsche Kloof, Tamboerskloof, University Estate, Vredehoek, Walmer Estate and Woodstock.

The Foreshore Freeway Bridge has stood in its unfinished state since construction officially ended in 1977. It was intended to be the Eastern Boulevard Highway in the city bowl, but is unfinished due to budget constraints.

The Atlantic Seaboard lies west of the City Bowl and Table Mountain, and is characterised by its beaches, cliffs, promenade and hillside communities. The area includes, from north to south, the neighbourhoods of Green Point, Mouille Point, Three Anchor Bay, Sea Point, Fresnaye, Bantry Bay, Clifton, Camps Bay, Llandudno, and Hout Bay. The Atlantic Seaboard has some of the most expensive real estate in South Africa particularly on Nettleton and Clifton Roads in Clifton, Ocean View Drive and St Leon Avenue in Bantry Bay, Theresa Avenue in Bakoven and Fishermans Bend in Llandudno. Camps Bay is home to the highest concentration of multimillionaires in Cape Town and has the highest number of high-priced mansions in South Africa with more than 155 residential units exceeding R20 million (or $US1.8 million).

The West Coast suburbs lie along the beach to the north of the Cape Town city centre, and include Bloubergstrand, Milnerton, Tableview, West Beach, Big Bay, Sunset Beach, Sunningdale, Parklands and Parklands North, as well as the exurbs of Atlantis and Melkbosstrand. The Koeberg Nuclear Power Station is located within this area and maximum housing density regulations are enforced in much of the area surrounding the nuclear plant.

The Northern Suburbs are predominantly Afrikaans-speaking, and include Belhar, Bellville, Blue Downs, Bothasig, Burgundy Estate, Durbanville, Edgemead, Brackenfell, Elsie's River, Eerste River, Kraaifontein, Goodwood, Kensington, Maitland, Monte Vista, Panorama, Parow, Richwood, Kraaifontein and Kuils River.

The Northern Suburbs are home to Tygerberg Hospital, the largest hospital in the Western Cape and second largest in South Africa

The Southern Suburbs lie along the eastern slopes of Table Mountain, southeast of the city centre. This area is predominantly English-speaking, and includes, from north to south, Observatory, Mowbray, Pinelands, Rosebank, Rondebosch, Rondebosch East, Newlands, Claremont, Lansdowne, Kenilworth, Bishopscourt, Constantia, Wynberg, Plumstead, Ottery, Bergvliet and Diep River. West of Wynberg lies Constantia which, in addition to being a wealthy neighbourhood, is a notable wine-growing region within the City of Cape Town, and attracts tourists for its well-known wine farms and Cape Dutch architecture.

The South Peninsula is generally regarded as the area South of Muizenberg on False Bay and Noordhoek on the Atlantic Ocean, all the way to Cape Point. Until recently, this predominantly English-speaking area was quite rural, however the population of the area is growing quickly as new coastal developments proliferate and larger plots are subdivided to provide more compact housing. It includes Capri Village, Clovelly, Fish Hoek, Glencairn, Kalk Bay, Kommetjie, Masiphumelele, Muizenberg, Noordhoek, Ocean View, Scarborough, Simon's Town, St James, Sunnydale and Sun Valley. South Africa's largest naval base is located at Simon's Town harbour, and close by is Boulders Beach, the site of a large colony of African penguins.

The Cape Flats is an expansive, low-lying, flat area situated to the southeast of the city centre.

Due to the region having a Mediterranean climate, the wettest months on the Cape Flats are from April to September, with 82% most of its rainfall occurring between these months. The rainfall patterns on the Cape Flats vary with longitude, such that the eastern parts get a minimum of 214mm per year and the central and western parts get 800mm per year. A significant portion of this water ends up in the Cape Flats Aquifer, which lie beneath the central and southern parts of the Cape Flats. Most of the land of the Cape Flats is used for residential areas, the majority of which are formal, but with several informal settlements present. Light industrial areas are also found in the area. A part of the land in the south-east is used for cultivation and contains many smallholdings.

The Helderberg consists of Somerset West, Strand, Gordons Bay and a few other suburbs which were previously towns in the Helderberg district. The district takes its name from the imposing Helderberg Mountain, which reaches a height of 1,137 metres (3,730 feet).

The city of Cape Town has vast experience in hosting major national and international sports events.

The Cape Town Cycle Tour is the world's largest individually timed cycle race – and the first event outside Europe to be included in the International Cycling Union's Golden Bike Series. It sees over 35,000 cyclists tackling a 109 km (68 mi) route around Cape Town. The Absa Cape Epic is the largest full-service mountain bike stage race in the world.

Some notable events hosted by Cape Town have included the 1995 Rugby World Cup, 2003 ICC Cricket World Cup, and World Championships in various sports such as athletics, fencing, weightlifting, hockey, cycling, canoeing, gymnastics and others.

Cape Town was also a host city to the 2010 FIFA World Cup from 11 June to 11 July 2010, further enhancing its profile as a major events city. It was also one of the host cities of the 2009 Indian Premier League cricket tournament.

Cape Town has a well-developed higher system of public universities. Cape Town is served by three public universities: the University of Cape Town (UCT), the University of the Western Cape (UWC) and the Cape Peninsula University of Technology (CPUT). Stellenbosch University, while not in the city itself, is 50 kilometres from the City Bowl and has additional campuses, such as the Tygerberg Faculty of Medicine and Health Sciences and the Bellville Business Park closer to the City.

Both the University of Cape Town and Stellenbosch University are leading universities in South Africa. This is due in large part to substantial financial contributions made to these institutions by both the public and private sector. UCT is an English-speaking institution. It has over 21,000 students and has an MBA programme that was ranked 51st by the Financial Times in 2006. It is also the top-ranked university in Africa, being the only African university to make the world's Top 200 university list at number 146. Since the African National Congress has become the country's ruling party, some restructuring of Western Cape universities has taken place and as such, traditionally non-white universities have seen increased financing, which has evidently benefitted the University of the Western Cape.

The Cape Peninsula University of Technology was formed on 1 January 2005, when two separate institutions – Cape Technikon and Peninsula Technikon – were merged. The new university offers education primarily in English, although one may take courses in any of South Africa's official languages. The institution generally awards the National Diploma.

Cape Town has also become a popular study abroad destination for many international college students. Many study abroad providers offer semester, summer, short-term, and internship programs in partnership with Cape Town universities as a chance for international students to gain intercultural understanding.

Cape Town International Airport serves both domestic and international flights. It is the second-largest airport in South Africa and serves as a major gateway for travelers to the Cape region. Cape Town has regularly scheduled services to Southern Africa, East Africa, Mauritius, Middle East, Far East, Europe and the United States as well as eleven domestic destinations.

Cape Town International Airport recently opened a brand new central terminal building that was developed to handle an expected increase in air traffic as tourism numbers increased in the lead-up to the 2010 FIFA World Cup. Other renovations include several large new parking garages, a revamped domestic departure terminal, a new Bus Rapid Transit system station and a new double-decker road system. The airport's cargo facilities are also being expanded and several large empty lots are being developed into office space and hotels.

The Cape Town International Airport was among the winners of the World Travel Awards for being Africa's leading airport.

Cape Town International Airport is located 18 km from the Central Business District.

Cape Town has a long tradition as a port city. The Port of Cape Town, the city's main port, is in Table Bay directly to the north of the CBD. The port is a hub for ships in the southern Atlantic: it is located along one of the busiest shipping corridors in the world. It is also a busy container port, second in South Africa only to Durban. In 2004, it handled 3,161 ships and 9.2 million tonnes of cargo.

Simon's Town Harbour on the False Bay coast of the Cape Peninsula is the main operational base of the South African Navy.

Until the 1970s the city was served by the Union Castle Line with service to the United Kingdom and St Helena. The RMS St Helena provided passenger and cargo service between Cape Town and St Helena until the opening of St Helena Airport.

Currently the cargo vessel M/V Helena, under AW Shipping Management, takes a limited number of passengers, between Cape Town and St Helena and Ascension Island on its voyages. Multiple vessels also take passengers to and from Tristan da Cunha, inaccessible by aircraft, to and from Cape Town. In addition NSB Niederelbe Schiffahrtsgesellschaft [de] takes passengers on its cargo service to the Canary Islands and Hamburg, Germany.

The Shosholoza Meyl is the passenger rail operations of Spoornet and operates two long-distance passenger rail services from Cape Town: a daily service to and from Johannesburg via Kimberley and a weekly service to and from Durban via Kimberley, Bloemfontein and Pietermaritzburg. These trains terminate at Cape Town railway station and make a brief stop at Bellville. Cape Town is also one terminus of the luxury tourist-oriented Blue Train as well as the five-star Rovos Rail.

Metrorail operates a commuter rail service in Cape Town and the surrounding area. The Metrorail network consists of 96 stations throughout the suburbs and outskirts of Cape Town.

Cape Town is the origin of three national roads. The N1 and N2 begin in the foreshore area near the City Center and the N7, which runs North toward Namibia.

The N1 runs East-North-East through Edgemead, Parow, Bellville, and Brackenfell. It connects Cape Town to major cities further inland, namely Bloemfontein, Johannesburg, and Pretoria An older at-grade road, the R101, runs parallel to the N1 from Bellville.

Khayelitsha, Township along N2 (2015)
The N2 runs East-South-East through Rondebosch, Guguletu, Khayelitsha, Macassar to Somerset West. It becomes a multiple-carriageway, at-grade road from the intersection with the R44 onwards. The N2 continues east along the coast, linking Cape Town to the coastal cities of Port Elizabeth, East London and Durban. An older at-grade road, the R101, runs parallel to the N1 initially, before veering south at Bellville, to join the N2 at Somerset West via the suburbs of Kuils River and Eerste River.

The N7 originates from the N1 at Wingfield Interchange near Edgemead. It begins, initially as a highway, but becoming an at-grade road from the intersection with the M5 onwards.

There are also a number of regional routes linking Cape Town with surrounding areas. The R27 originates from the N1 near the Foreshore and runs north parallel to the N7, but nearer to the coast. It passes through the suburbs of Milnerton, Table View and Bloubergstrand and links the City to the West Coast, ending at the town of Velddrif. The R44 enters the east of the metro from the north, from Stellenbosch. It connects Stellenbosch to Somerset West, then crosses the N2 to Strand and Gordon's Bay. It exits the metro heading south hugging the coast, leading to the towns of Betty's Bay and Kleinmond.

Of the three-digit routes, the R300, is an expressway linking the N1 at Brackenfell to the N2 near Mitchells Plain and the Cape Town International Airport. The R302 runs from the R102 in Bellville, heading north across the N1 through Durbanville leaving the metro to Malmesbury. The R304 enters the northern limits of the metro from Stellenbosch, running NNW before veering west to cross the N7 at Philadelphia to end at Atlantis at a junction with the R307. This R307 starts north of Koeberg from the R27 and, after meeting the R304, continues north to Darling. The R310 originates from Muizenberg and runs along the coast, to the south of Mitchell's Plain and Khayelitsha, before veering north-east, crossing the N2 west of Macassar, and exiting the metro heading to Stellenbosch.

Cape Town, like most South African cities, uses Metropolitan or "M" routes for important intra-city routes, a layer below National (N) roads and Regional (R) routes. Each city's M roads are independently numbered. Most are at-grade roads. However, the M3 splits from the N2 and runs to the south along the eastern slopes of Table Mountain, connecting the City Bowl with Muizenberg. Except for a section between Rondebosch and Newlands that has at-grade intersections, this route is a highway. The M5 splits from the N1 further east than the M3, and links the Cape Flats to the CBD. It is a highway as far as the interchange with the M68 at Ottery, before continuing as an at-grade road.

Cape Town suffers from the worst traffic congestion in South Africa.

Golden Arrow Bus Services operates scheduled bus services in the Cape Town metropolitan area. Several companies run long-distance bus services from Cape Town to the other cities in South Africa.

Cape Town has a public transport system in about 10% of the city, running north to south along the west coastline of the city, comprising Phase 1 of the IRT system. This is known as the MyCiTi service.

MyCiTi Phase 1 includes services linking the Airport to the Cape Town inner city, as well as the following areas: Blouberg / Table View, Dunoon, Atlantis and Melkbosstrand, Milnerton, Paarden Eiland, Century City, Salt River and Walmer Estate, and all suburbs of the City Bowl and Atlantic Seaboard all the way to Llandudno and Hout Bay.

The MyCiTi N2 Express service consists of two routes each linking the Cape Town inner city and Khayelitsha and Mitchells Plain on the Cape Flats.

The service use high floor articulated and standard size buses in dedicated busways, low floor articulated and standard size buses on the N2 Express service, and smaller 9-metre (30-foot) Optare buses in suburban and inner city areas. It offers universal access through level boarding and numerous other measures, and requires cashless fare payment using the EMV compliant smart card system, called myconnect. Headway of services (i.e. the time between buses on the same route) range from 3 mins to 20 mins in peak times to 60 minutes during quiet off-peak periods.

Cape Town has two kinds of taxis: metered taxis and minibus taxis. Unlike many cities, metered taxis are not allowed to drive around the city to solicit fares and instead must be called to a specific location.

Cape Town metered taxi cabs mostly operate in the city bowl, suburbs and Cape Town International Airport areas. Large companies that operate fleets of cabs can be reached by phone and are cheaper than the single operators that apply for hire from taxi ranks and Victoria and Alfred Waterfront. There are about one thousand meter taxis in Cape Town. Their rates vary from R8 per kilometre to about R15 per kilometre. The larger taxi companies in Cape Town are Excite Taxis, Cabnet and Intercab and single operators are reachable by cellular phone. The seven seated Toyota Avanza are the most popular with larger Taxi companies. Meter cabs are mostly used by tourists and are safer to use than minibus taxis.

Minibus taxis are the standard form of transport for the majority of the population who cannot afford private vehicles. Although essential, these taxis are often poorly maintained and are frequently not road-worthy. These taxis make frequent unscheduled stops to pick up passengers, which can cause accidents. With the high demand for transport by the working class of South Africa, minibus taxis are often filled over their legal passenger allowance. Minibuses are generally owned and operated in fleets.